DEF201 Publications

Type 1 interferon gene transfer enhances host defense against pulmonary Streptococcus pneumoniae infection via activating innate leukocytes
Daniela Damjanovic, Amandeep Khera, Maria Fe Medina, Jane Ennis, Jeffrey D. Turner, Jack Gauldie, and Zhou Xing
Mol Ther - Meth & Clin Dev 2014  1(5)


Protection against Chikungunya virus induced arthralgia following prophylactic treatment with adenovirus vectored interferon (mDEF201)
Ashley Dagley, Jane Ennis, Jeffrey D. Turner, Kerry A. Rood, Arnaud J. Van Wettere, Brian B. Gowen, Justin G. Julander
Antiviral Res. 2014 108:1-9.


Single-dose intranasal treatment with DEF201 (adenovirus vectored consensus interferon) prevents lethal disease due to Rift Valley fever virus challenge
Brian B. Gowen, Jane Ennis, Kevin W. Bailey, Zachary Vest, Dionne Scharton, Eric J. Sefing, Jeffrey D. Turner.
Viruses 2014 6(3):1410-23


Effects of Nasal or Pulmonary Delivered Treatments with an Adenovirus Vectored Interferon (mDEF201) on Respiratory and Systemic Infections in Mice Caused by Cowpox and Vaccinia Viruses 
Donald F. Smee, Min-Hui Wong, Brett L. Hurst, Jane Ennis, Jeffrey D. Turner
PLoS One 2013 8(7): e68685


Extended protection against phlebovirus infection conferred by recombinant adenovirus expressing consensus interferon (DEF201) 
Brian B. Gowen, Jane Ennis, Eric J. Stefing, Min-Hui Wong, Kie-Hoon Jung, Jeffrey D. Turner
Antimicrobial Agents and Chemotherapy 2012 56(8): 4168-74


Use of Recombinant Adenovirus Vectored Consensus IFN-a to Avert Severe Arenavirus Infection
Brian B. Gowen, Jane Ennis, Andrew Russell, Eric J. Sefing, Min-Hui Wong, Jeffrey Turner
PLoS ONE 2011 6(10): e26072


Therapy and Long-Term Prophylaxis of Vaccinia Virus Respiratory Infections in Mice with an Adenovirus-Vectored Interferon Alpha (mDEF201)
Donald F. Smee, Min-Hui Wong, Andrew Russell, Jane Ennis, Jeffrey D. Turner
PLoS ONE 2011 6(10): e26330


Treatment of Yellow Fever Virus with an Adenovirus-Vectored Interferon, DEF201, in a Hamster Model
Justin G. Julander, Jane Ennis, Jeffrey Turner, and John D. Morrey
Antimicrobial Agents and Chemotherapy 2011 55(5): 2067-2073


Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model
Yohichi Kumaki, Jane Ennis, Ramtin Rahbar, Jeffrey D. Turner, Miles K. Wandersee,
Aaron J. Smith, Kevin W. Bailey, Zachary G. Vest, Jason R. Madsen, Joseph K.-K. Li, Dale L. Barnard
Antiviral Research 2011 89: 75-82


ZMAbs Publications

mAbs and Ad-Vectored IFN-a Therapy Rescue Ebola-Infected  Nonhuman Primates When Administered  After the Detection of Viremia and Symptoms
Xiangguo Qiu,  Gary Wong, Lisa Fernando, Jonathan Audet, Alexander Bello, Jim Strong,  Judie B. Alimonti, Gary Kobinger
Science Translational Medicine 2013 5(207): 1-11


Monoclonal Antibodies Combined with Adenovirus-Vectored Interferon Significantly Extend the Treatment Window in Ebola Virus-Infected Guinea Pigs
Xiangguo Qiu, Gary Wong, Lisa Fernando, Jane Ennis, Jeffrey D. Turner, Judie B. Alimonti, Xiaojian Yao, Gary P. Kobinger
Journal of Virology 2013 87(13): 7754-7757


Successful Treatment of Ebola Virus–Infected Cynomolgus Macaques with Monoclonal Antibodies
Xiangguo Qiu, Jonathan Audet, Gary Wong, Stephane Pillet, Alexander Bello, Teresa Cabra, Jim E. Strong, Frank Plummer, Cindy R. Corbett, Judie B. Alimonti and Gary P. Kobinger
Science Translational Medicine 2012 4(138): 1-11


Ebola GP-Specific Monoclonal Antibodies Protect Mice and Guinea Pigs from Lethal Ebola Virus Infection
Xiangguo Qiu, Lisa Fernando, P. Leno Melito, Jonathan Audet, Heinz Feldmann, Gary Kobinger, Judie B. Alimonti, and Steven M. Jones
PLoS Neglected Tropical Diseases 2012 6(3): e1575


Characterization of Zaire ebolavirus glycoprotein-specific monoclonal antibodies
Xiangguo Qiu, Judie B. Alimontia, P. Leno Melitoa, Lisa Fernandoa, Ute Ströhera, and Steven M. Jones
Clinical Immunology 2011 141(2): 218-227